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Malignant cancers kill people primarily because they invade and spread (metastasise) to distant organs. Advances in surgical technique means that tumours arise in relatively few places from which they cannot be excised successfully. However, should the cancer spread before the operation then the patients' outlook is substantially poorer than it would be if the tumour remained localised.
Understanding the ways by which cancer cells spread, at the most fundamental and biochemical level, may offer hope for novel therapies which block this process. Study of the mechanisms of tumour invasion and metastasis, in other words how cancers get from A to B, constitutes the major research of the Dimbleby Department of Cancer Research.
The work is expensive. It demands the highest quality of equipment and facilities to support the dedication of the research team.
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